Synopsis-On a school trip, high school senior Peter Parker visits a Columbia University genetics laboratory with his friend Harry Osborn and his crush Mary Jane Watson. There, a genetically engineered "super spider" bites him and he falls ill after returning home. Meanwhile, Harry's scientist father Norman Osborn, founder and owner of Oscorp, tries to secure an important military contract. He experiments on himself with an unstable performance-enhancing chemical and goes insane, killing his assistant.
The next day, Peter finds he is no longer near-sighted and has developed spider-like abilities. He can also shoot webs out of his wrists and has quick reflexes, superhuman speed and strength, and a heightened ability to sense danger. Brushing off his uncle Ben's advice that "with great power comes great responsibility", Peter considers impressing Mary Jane with a car. He enters an underground wrestling tournament to win the money for it and wins his first match against Bonesaw McGraw, but the promoter cheats him out of his earnings. When a thief robs the promoter's office, Peter allows him to escape in retaliation. Moments later, he discovers Ben was carjacked and killed. Peter pursues the carjacker, only to realize it was the thief he let escape. The carjacker flees but dies after falling out a window. Meanwhile, a crazed Norman interrupts a military experiment by Oscorp's corporate rival Quest Aerospace and kills several people.
Upon graduating, Peter begins using his abilities to fight injustice, donning a spandex costume and the persona of Spider-Man. J. Jonah Jameson, publisher of the Daily Bugle newspaper, hires Peter as a freelance photographer, since he is the only person providing clear images of Spider-Man. Norman, upon discovering Oscorp's board plans to oust him in order to sell the company to Quest, assassinates them. Jameson dubs the mysterious killer the "Green Goblin".
The Goblin offers Spider-Man a place at his side, but Peter refuses. They fight and Peter is wounded. At Thanksgiving dinner, Peter's aunt May invites Mary Jane, Harry, and Norman. During the dinner, Norman sees the wound and realizes Peter's identity. Thinking the only way to defeat Peter is to attack those special to him, Norman later attacks May, forcing her to be hospitalized.
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